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Entry Date: January 2025

Job code and Title: Postdoctoral Scholar

Department ID and Name: 694060 Pathology

School: Medicine

Location: Wolstein Research Building 2103 Cornell Rd. Cleveland, Oh

Supervisor Name and Title: Tyler E. Miller, MD, PhD, Principal Investigator

POSITION OBJECTIVE

The Postdoctoral Scholar will lead innovative research projects focused on the development and evaluation of immunotherapies for brain tumors, with an emphasis on CAR-T cell therapy. This position provides an exciting opportunity to leverage cutting-edge immunological and molecular techniques in patient-derived  models, including primary-tissue organoids. The scholar will design and execute experimental strategies aimed at translating novel immunotherapy approaches from bench to bedside, in alignment with the lab's mission to transform brain tumor patient care through pioneering research. The Postdoctoral Scholar will work with the principal investigator and a multidisciplinary team of researchers to generate data that will inform novel therapeutic strategies for brain tumor immunotherapies.

ESSENTIAL FUNCTIONS

1. Immunotherapy Research: Independently design, plan, and execute experiments involving CAR-T cell engineering, optimization, and evaluation using advanced cellular, molecular, and immunological techniques in patient-derived glioblastoma models (50%).
2. Data Analysis and Manuscript Preparation: Perform thorough data analysis, create comprehensive records, write manuscripts, and prepare figures for high-impact publications. Present research findings in lab meetings and at national/international conferences (20%).
3. Experimental Design and Grant Development: Contribute to the conceptualization and development of grant proposals, assisting in the identification of research directions and novel immunotherapy strategies (10%).
4. Collaboration and Mentorship: Collaborate effectively within a multidisciplinary team, provide mentorship and guidance to junior lab members, including graduate students and research assistants, fostering a supportive and productive research environment (15%).

NONESSENTIAL FUNCTIONS

1. Lab Organization and Maintenance: Assist in the general maintenance of laboratory equipment and organization as needed (5%).

CONTACTS

Department: Daily interaction with the principal investigator and lab members to discuss ongoing projects and results.

University: Regular contact with collaborators across multiple departments and centers within the university. Occasional communication with administrative support and research offices.

External: Occasional interactions with external collaborators, vendors, institutions, and funding agencies.

Students: Regular interactions and mentorship of graduate and undergraduate students.

SUPERVISORY RESPONSIBILITIES

Provide mentorship and guidance to graduate students, research assistants, and other junior lab personnel.

QUALIFICATIONS

Education: PhD in Immunology, Cancer Biology, Molecular Biology, or a related discipline.

Experience: Demonstrated expertise in immunotherapy, preferably with hands-on experience in CAR-T cell research and related molecular techniques. Prior experience in tumor immunology and single-cell methodologies is highly desirable.

REQUIRED SKILLS

1. Extensive experience with CAR-T cell design, engineering, and functional evaluation in vitro and in vivo.
2. Proficiency with molecular biology techniques including CRISPR-Cas9 gene editing, flow cytometry, multiplex immunofluorescence, and RNA sequencing.
3. Proven record of high-impact scientific publications.
4. Exceptional analytical and problem-solving skills; must demonstrate innovation, independence, and scientific rigor.
5. Excellent written and oral communication skills; capable of clearly presenting complex scientific data and collaborating effectively within interdisciplinary teams.
6. Strong organizational skills, ability to manage multiple projects simultaneously, and prioritize tasks effectively.
7. Commitment to fostering a collaborative, diverse, and inclusive research environment.
8. Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable, and a self-starter.
9. Excellent organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy and follow-through on assigned tasks.
10. Ability to work with sensitive information and maintain confidentiality. 
11. Familiarity with policies and procedures of lab and adhere to chemical and biological safety and manage them.
12. Computational knowledge necessary for research
13. Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health of the cellular models.
14. Ability to meet consistent attendance.

WORKING CONDITIONS

The employee may be exposed to bloodborne pathogens and infectious materials. Personal protective equipment (gloves, masks, eye protection) will be provided. Occasional weekend and evening work may be required depending on project needs.

HOW TO APPLY
Applicants may send inquiries containing a Curriculum Vitae (CV) with a list of publications and contact information with references to the Principal Investigator, Tyler Miller at tymiller@case.edu.

EEO statement 

°Ç¸çºÚÁÏ is an equal opportunity employer. All applicants are protected under federal and state laws and university policy from discrimination based on race, color, religion, sex, sexual orientation, gender identity or expression, national or ethnic origin, protected veteran status, disability, age and genetic information.

Reasonable Accommodation
°Ç¸çºÚÁÏ complies with the Americans with Disabilities Act regarding reasonable accommodations for applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity by phone at 216.368.3066 or by email at equity@case.edu. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.