The Panicker lab investigates the molecular mechanisms that drive pathology in Dementia with Lewy bodies (DLB), Parkinson’s Disease (PD), and Alzheimer’s Disease (AD), with the eventual goal of developing therapeutics that block or slow disease progression. We study cell-death pathways in neurodegenerative diseases, and how neuroinflammation (primarily mediated by microglial cells in the brain) contributes to the pathogenesis of neurologic disorders.
Research Information
Research Interests
The Panicker lab investigates the molecular mechanisms that drive pathology in Dementia with Lewy bodies (DLB), Parkinson’s Disease (PD), and Alzheimer’s Disease (AD), with the eventual goal of developing therapeutics that block or slow disease progression.We study cell-death pathways in neurodegenerative diseases, and how neuroinflammation (primarily mediated by microglial cells in the brain) contributes to the pathogenesis of neurologic disorders.
Our current projects explore the mechanisms and consequences of Nod-Like Receptor Protein-3 (NLRP3) inflammasome assembly by using cellular and molecular approaches in transgenic-mouse and iPSC disease models of DLB, PD and AD.
Publications
Selected Publications
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Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. (2022). Neuron. Epub ahead of print. PMID: 35654037.
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Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. (2022). Proceedings of the National Academy of Sciences U S A. Epub 2022 Apr 8. PMID: 35394877; PMCID: PMC9169780.
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Pirooznia SK, Wang H, Panicker N, Kumar M, Neifert S, Dar MA, Lau E, Kang BG, Redding-Ochoa J, Troncoso JC, Dawson VL, Dawson TM. (2022). Science Advances. Epub 2022 Apr 1. PMID: 35363524.
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Panicker N, Ge P, Dawson VL, Dawson TM. (2021). Journal of Cell Biology PMID: 33749710; PMCID: PMC8103423.
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Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. (2020). Journal of Clinical Investigation. PMID: 32597830; PMCID: PMC7410064.
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Saminathan H, Charli A, Luo J, Panicker N, Gordon R, Hostetter JM, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. (2020). European Journal of Pharmacology. PMID: 32565338; PMCID: PMC7483871.
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Panicker N, Kanthasamy A, Kanthasamy AG. (2019). Aging (Albany NY). Epub 2019 Aug 27. PMID: 31454793; PMCID: PMC6738402.
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Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS. (2019). Neuron. Epub 2019 Jun 26. PMID: 31255487; PMCID: PMC6706297.
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Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. (2019). Journal of Experimental Medicine. PMID: 31036561; PMCID: PMC6547864.