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The RNA profiling core provides access to expertise and infrastructure for advanced transcriptomic profiling approaches, including Ribosome Profiling (mapping of translating ribosomes), CLIP (mapping of RNA-protein binding sites), 3'-end profiling (assessing alternative polyadenylation). The core assists in designing effective transcriptomic profiling experiments, prepares the sequencing libraries, coordinates the Next-Generation Sequencing, and provides project–specific data analysis.

Recent Publications from the Core

• Dubey, Ashutosh P., et al. "KRBP72 facilitates ATPase-dependent editing progression through a structural roadblock in mitochondrial A6 mRNA." Nucleic Acids Research (2024): gkae1153.
• Roshan, Poonam, et al. "Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression." bioRxiv (2024): 2024-06.
• Rao, Anupama, et al. "The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration." Development 150.20 (2023).
• Mucha, Bartosz, et al. "Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation." Nature Communications 13.1 (2022): 6614.
• Guenther, Ulf-Peter, et al. "The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs." Nature 559.7712 (2018): 130-134.