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The Applied Functional Genomics Core (AFGC) offers functional genomic study design and a highly standardized, top-to-bottom platform for conducting RNA isolation, Illumina-based RNA sequencing, and bioinformatics on a wide variety of clinical sample types.  We provide workflows that are optimized for many difficult sample types, such as ultra-low input (biopsies, laser capture, small cell numbers), 10X Genomics single cell-multiomic sequencing (scRNA-/snRNA-/ATAC-Seq), and Spatial Profiling via 10X Genomics' Visium CytAssist and Nanostring's GeoMx/nCounter platforms. Our analysis tools can integrate multiple data types—whether clinical or functional—in the bioinformatics analysis to uncover biomarkers or correlates.

Organization Affiliations: Case Comprehensive Cancer Center (Integrated Genomics Shared Resource), Rustbelt Center for AIDS Research, Systems Biology and Bioinformatics Program.